Complement in Human Brain Health: Potential of Dietary Food in Relation to Neurodegenerative Diseases

The complement pathway is a major component of the innate immune system, which critical for recognizing and clearing pathogens that rapidly react to defend body against external pathogens. Many components this are expressed throughout brain play beneficial role in synaptic pruning developing central nervous system (CNS). However, excessive complement-mediated aging or injured may contributing wide range neurodegenerative diseases. Complement Component 1q (C1q), an initiating recognition molecule classical pathway, can interact with variety ligands perform functions physiological pathophysiological conditions CNS. This review considers function immunomodulatory mechanisms C1q; emerging C1q on developing, aging, pathological CNS; relevance diseases; and, finally, it summarizes foods effects diseases via highlights need further research clarify these roles. paper aims provide references subsequent study food related C1q, complement, diseases, human health.